Exuberant Fibroblast Activity Compromises Lung Function Via ADAMTS4
Date: February 4, 2021
Previous studies of host determinants of disease severity following respiratory viral infection have overwhelmingly focused on the role of migrating immune cells in mediating immunopathology. In this study, we identified activated lung fibroblasts as critical regulators of localized immune responses through the production of the extracellular matrix protease ADAMTS-4. In human cases of influenza, the level of ADAMTS-4 in the lower respiratory tract was a strong predictor of prolonged respiratory failure and mortality.
Presenter: David Boyd, PhD (St. Jude Children’s Research Hospital)
Moderator: E. Kaity Allen, PhD (St. Jude Children’s Research Hospital)
Panelists: Paul Thomas, PhD (St. Jude Children’s Research Hospital)Jay Mizgerd, Sc.D (Boston University)
Katrina Traber, MD, PhD (Boston University)
Stephania Cormier, PhD (University of Louisiana)
